Continuous positive airway pressure (CPAP) device is a gold standard treatment for Obstructive sleep apnea (OSA). It gently blows pressurized air through a person’s airway at a constant pressure that keeps the throat from collapsing. Dental appliances, which are less bulky than CPAP device, can be prescribed for OSA. However, they are not effective for everyone with OSA like the CPAP device [1]. The aim of the project is to design, develop and evaluate a flexible hybrid electronic sleep monitoring platform that can be integrated with a CPAP device. The monitoring system will consist of printed CO2 sensor, organic light emitting diode and organic photodetector for photoplethysmograph sensor, and conventional silicon integrated circuit (IC) chips for accelerometer sensor, microphpne, power, memory, signal conditioning, and communications. Use of flexible hybrid electronics will combine the processing and storage capabilities of silicon ICs with the flexibility, and cost benefits of printed and organic electronics. The system will allow measurement of physiological parameters; end-tidal CO2, blood oxygen saturation, heart rate and breathing as well as accelerometry and breathing sound to detect sleep latency, onset and duration. The platform will have potential to better evaluate the effectiveness of CPAP treatment and document sleep patterns of patients wearing the CPAP device.