Funded projects - Impact program

Note that this list is not exhaustive, and will be updated regularly.

Summary

Obstructive Sleep Apnea (OSA) is a condition that affects 3-7% of the general population and 40% of patients with obesity. Mandibular Advancement Device (MAD) that opens the oropharyngeal airspace by pushing the lower mandible forward is designed to treat OSA. Although Continuous Positive Airway Pressures (CPAP) are the gold  standard treatment, they are bulky, cause physical and social discomfort and are known to have low rates of adherence to treatment. In contrast, MADs are as effective, less bulky and cause little if any social discomfort. Hence, adherence to treatment for MADs is greater than for CPAP [1]. The aim of this project is to design, develop and evaluate a cost effective intraoral smart MAD integrating a multi sensor platform and EEG electrodes. The multi sensor platform will consist of multiple units: sensors such as pulse oximeter, accelerometer, analog front-end, power management and signal processing unit, power supply/energy harvesting unit and a wireless transmitter unit. The smart MAD will allow intraoral measurement of physiological  parameters such as blood oxygen saturation, EEG signal, heart and breathing rate as well as accelerometry to detect sleep latency, onset and duration. The platform will have potential to better evaluate the effectiveness of MAD and document sleep patterns of patients wearing the MAD.

Partners

  • iMD Research
  • Metropole Dentaire Terrebonne
  • McGill University

Summary

Genetic advances over the past 10 years have led to the development of several targeted therapies for lung, breast and colon cancer. However, there are a number of factors that limit the optimal use of these innovations, including the high cost of the organizational process associated with molecular testing, and their late use in the patient’s journey. Recently, the prospect of obtaining non-invasive, cost-effective and timely triggers for diagnostic & therapy has emerged from a discipline known as Radiomics. Radiomics leverages advances in artificial intelligence (AI) for the quantitative extraction of high-dimensional imaging features with promising predictive and prognostic indications. Nonetheless, a lack of evidence from large enough cohort validation, and the transdisciplinarity necessary for this process appears to be a methodological barrier spanning from the physics and treatment of medical imaging, the analysis of big data in health (clinical, biological, genetic and epigenetic), to the required expertise in machine & deep learning. The proposed project aims at operationalizing at a large scale Imagia’s clinical evidence ecosystem, called Evidens, to enable a sharp decrease in the cost of discovering predictive and prognostic cancer imaging biomarkers, by pursuing and applying fundamental advances in machine learning, data privacy, distributed computing and biostatistics. This multidisciplinary project will contribute to the mission of Evidens, to facilitate a universal access to precision medicine by fostering AI-first collaborations, federating the learning originating from patient data across partnering hospitals and uniting clinical and AI expertise.

Partners

  • Imagia
  • Research Cancer Society
  • The Research Institute of the McGill University Health Center
  • University of Montreal
  • McGill University

Summary

In this project, we propose the development of innovative decision support tools to improve the delivery of home care and services. The project is articulated around two main research topics: A) the development of optimization model and solution approaches for supply (care givers) and demand (patients) management; and B) the development of optimization techniques specific to construct complex personnel schedules  in a dynamic and multi-criteria context. The project’s innovation is based on the formulation and design of new optimization approaches that integrate techniques from data science, artificial intelligence and combinatorial optimization. They will be adapted to solve complex and large-scale problems in order to make better (recurrent) decisions in practice.

Partners

  • Alayacare
  • ApStat Technologies
  • École polytechnique de Montréal

Summary

Spinal surgeries are amongst the most complex, from a biomechanical perspective, considering the spine is an intricate
mechanical system. Conventional training of spine surgeries is very costly and not optimized towards fast skillset
acquisition. The purpose of this project is to perform research, development and experimental evaluation of a new virtual
reality physics driven platform, inclusive of graphic and haptic feedback, focusing on a novel spinal surgical procedure.

Partners

  • CAE
  • Depuy/Synthes (Johnson & Johnson)
  • McGill University
  • Miami University
  • Université de Lille

Summary

The goal of this research is to improve breast cancer local control and reduce treatment side effects by demonstrating that a new cold plasma technology, which generates locally specific reactive oxygen species, has an additive positive treatment impact when combined with conventional radiotherapy.

Partners

  • NexPlasmaGen
  • InstaDesign
  • The Research Institute of the McGill University Health Center
  • McGill University

Summary

According to the World Health Organization (WHO), nearly 7.7 million new cases of dementia and Alzheimer’s are identified each year around the world. Moreover, the incidence of concussions in sports and their consequences for mental health have become of concern. Finally, despite a relatively low prevalence, brain cancers have a very poor prognosis, with a survival expectancy of less than one year for the most common and aggressive form, the glioblastoma multiform. Positron emission tomography (PET) is the imaging modality that is the most sensitive for studying non-invasively and in vivo these diseases at the biochemistry and cerebral metabolism levels, with the potential for earlier diagnosis, a more refined characterization of the type of pathology, but also a better understanding of the causes at the source of these diseases. Currently available PET scanners lack precision for detailed study of the brain. This project aims to develop a dedicated high performance PET scanner that will image the human brain with a spatial resolution 2 times higher than that reached with the best existing technology. At the planned resolution of 1.25 mm, it becomes possible to characterize tumor infiltration and tumor heterogeneity, determining factors of the evolution of aggressive cancers such as glioblastoma. It also becomes possible to follow in real-time osmotic opening of the blood-brain barrier to promote the transport of drugs to the tumor. Such a PET scanner will also allow molecular imaging of intermediate animals for biomedical research with unmatched precision.

Partners

  • IR&T
  • Charles Rivers Laboratories
  • Novalgo
  • Research Cancer Society
  • Université de Sherbrooke
  • The Research Institute of the Sherbrooke University Health Center
  • Harvard University

Summary

The main objective of this research proposal is to integrate a workflow of 2D/3D elastic vascular roadmap during arterial endovascular intervention based on real-time detection of patient motion, guidewire/catheter localization and realistic biomechanical model of vascular structures and surrounding tissues. This workflow will be first adapted for advanced aortic aneurysm endovascular repair. A generic approach will allow its use for other endovascular abdominal intervention (aorto-iliac, renal angioplasty/stenting, embolization procedures) and also intracranial intervention.

Partners

  • Siemens Healthineers
  • The Research Institute of the Montreal University Health Center (CRCHUM)
  • McGill University
  • Toronto University
  • Université de Montréal (UdeM) / École de technologie supérieure (ETS)

Summary

To demonstrate the safety and feasibility of ECG data collection using the SIG.ECG 1 Contactless Acquisition System in a hospital and outpatient clinic setting.
To demonstrate the diagnostic concordance between the standard ECG or in-hospital telemetry and the SIG.ECG 1 Contactless Acquisition System.

Partners

  • SIGNUM
  • HSCM

Summary

NXTSens has developed an implantable continuous monitoring, stand-alone and potentially
mass-producible microsensor for accurate monitoring of tissue pressure and temperature in
damaged limb muscles to better diagnose acute compartment syndrome (ACS). The proposed research will involve several sub-projects that include: i) develop appropriate surgical models for the accurate and reproducible placement of the microsensors in rodent compartments; ii) test the performance of a prototype microsensor in a relevant cadaver model.

Partners

  • NXT Sens
  • The Research Institute of the McGill University Health Center

Partners

  • Sensoreal
  • Parallex BioAssays
  • Université Laval

Summary

Perform a technology validation / comparative study on the immunological response to the influenza vaccine in patients using the needle-free injector MED-JET H4 in comparison to traditional needles to validate the efficacy of the technology.

Partners

  • MIT Canada
  • The Research Institute of the McGill University Health Center

Summary

Develop innovative decision support tools that enable health professionals to offer more personalized home care to the aging population by making the best use of available human and material resources.

Partners

  • Alayacare
  • VHA
  • Ecole polytechnique de Montréal

Partners

  • Medvalgo
  • 360Medlink
  • Université de Montréal (UdeM)
  • École polytechnique de Montréal

Funded projects - FSISSS program

Note that this list is not exhaustive, and will be updated regularly.

Summary

In 2016, the Ministry of Health made reducing wait time in emergency rooms a priority following a report indicating that Quebec had the longest wait times in the developed world.

The proposed project is an evaluation study in a live environment of a triage and diagnostic application (DXA) for emergency care. DXA is a tool designed to facilitate the diagnostic process and assist in triage by simplifying urgent primary care encounters. This application is patient-centered and facilitates the transmission of important information throughout the meeting process between medical staff and patients. DXA allows the automation and systematization of the initial medical questionnaire. The application was designed by physicians to address gaps in initial contact with patients during an emergency room visit (lack of time, productivity pressure, etc.). It is not a simple symptom checker, but a dynamic questionnaire with a knowledge base of more than 550 pathologies. The objective of the tool is to secure triage, improve diagnostic accuracy, reduce the average length of stay in the emergency department, and reduce the use of medical tests/investigations without specific indications. Ultimately, DXA’s goal will be to increase the efficiency and above all the quality and safety of care to enable better patient outcomes.

Partners

  • CHUM
  • Dialogue

Summary

In Quebec, the health care system faces major shortcomings such as fragmentation of care, lack of coordination of services, and poor data management and data sharing. Moreover, data from electronic medical records in primary health care are difficult to access and clinical information does not follow the patient, making coordination and integration of care difficult. In addition, there is a lack of clinical and administrative indicators for conducting comparative effectiveness studies and evaluating the effects of chronic pain management programs on patient outcomes. These shortcomings are reflected, in particular, in the accessibility and continuity of services offered but also in the decreased capacity to meet the needs of people suffering from chronic pain.

In order to address these gaps, this project aims to build a learning health system in chronic pain using an integrated digital platform. The learning health system will be based on inter and intra-institutional trajectories that support the notion of integrated care and provide personalized and patient-centered care while ensuring cross-functional coordination of care and continuity of clinical information. Finally, the platform will integrate machine learning and artificial intelligence using predictive algorithms to provide personalized patient care, thereby contributing to a digital transformation with significant benefits for the health system, Stakeholders and the patient.

Partners

  • McGill University Health Center
  • Akinox

Summary

Due to the lack of clinical tools to help physicians guide and personalize treatment plans for knee problems, the current care pathway is inefficient and costly (both for the Quebec health care system and the patient). Knee Kinesiography is a 3D examination of the knee function, performed during loading and movement. This is made possible thanks to the KneeKGTM system, a Quebec innovation, which is to the knee what the electrocardiogram is to the heart. It allows the detection of mechanical biomarkers related to the symptoms, development and progression of knee problems. Since 2009, the implementation of knee kinesiography in the private healthcare sector in Quebec has established the organizational requirements to promote its integration into the knee care pathway. A large randomized Québec clinical study confirms that patients benefiting from the knee care pathway integrating knee kinesiography are more satisfied, report an improvement in their symptoms, functions and quality of life compared to patients in the regular care pathway. Since the clinical context and the organizational structures are different within the public healthcare sector, the objective of this project is to carry out an analysis of the implementation of knee kinesiography within the RSSS institutions in order to assess the factors influencing the integration, acceptance and the use of this innovation in the context of the public healthcare, involving different healthcare professionals. This evaluation will be instrumental in planning deployment of the KneeKG system throughout the RSSS, in Canada and internationally.

Partners

  • CISSS de la Montérégie-Centre
  • CIUSSS Nord-De-L’île-de-Montréal
  • Emovi Inc.

Summary

In its early development, the respiratory system of newborns and infants is exceptionally vulnerable to diseases. In Quebec only, it is estimated that more than 300,000 children suffer from asthma, the most common childhood chronic disease. Most of these respiratory diseases are often preventable through early and accurate diagnosis. However, current lung function tests in infants are considerable long, invasive, and frequently involve sedation usually contraindicated in newborns.
THORASYS has developed a new effortless and non-invasive product aimed specifically at the 0–2 years age group, called the tremoflo N-100, a modified version of the current tremoflo C-100 AOS Oscillometry System, that includes an optimized flow head that improves the patient’s comfort and measurements accuracy.
Preliminary results using mechanical loads with typical neonate’s impedance values, shows comparable results to the measurements obtained with the wavetube (non-commercial established gold standard technique for infants). Therefore, the purpose of this project is to conduct a clinical study in a group of 30 infants from 0 to 2 years of age, to validate that the results obtained with the tremoflo N-100 are comparable to those produced by the wavetube. Such validation would allow for further development towards a device that could be routinely employed in the assessment and care of infants, thus, potentially reducing the mortality rate, as well as, the costs associated with these diseases.

Partners

  • McGill University Health Center
  • Système Médicaux Thoraciques Thorasys Inc.

Summary

Our project aims to deploy and evaluate a new approach using a Remote Patient Telemonitoring (RPM) and artificial intelligence (AI) solutions at the Lakeshore General Hospital (HGL). It will be based on the integration of coaching and self-management strategies using machine learning and algorithms, to predict and prevent emergency room visits and admissions to the hospital. The primary endpoints will be the occurrence of exacerbation of the condition and the number of emergency room visits or hospitalizations for exacerbation of COPD within 15 months of study enrollment (12 months of monitoring using the proposed solution and three monitoring after disconnection to check the number of occurrence of exacerbations if there were any). Secondary measures will include satisfaction of patients and health care providers with services, health-related quality of life, COPD-related symptoms, social support, level of anxiety and depression. The direct and indirect costs of services will be collected to analyze the financial viability of this solution in relation to regular health services with an average goal of 55% in reducing current costs for emergency department visits and combined hospitalizations.

Partners

  • CIUSSS du Centre-Ouest-de-l’Île-de-Montréal
  • HEC Montréal
  • Alayacare

Summary

In Quebec and several industrialized countries, the number of histopathological analyzes is constantly increasing because of higher life expectancy which, consequently, increases the incidence of cancer, but also because of the success of cancer programs screenings. Recent studies have shown that the digital conversion of a pathology service treating a volume of specimen similar to that of the CHUM allows an efficiency gain for the work of the pathologists and generates time savings for the laboratory personnel. In addition to simplifying the workflow, the digital pathology platform contributes to greater productivity, improved diagnostic reliability, good sample traceability, and minimizes the waste of time associated with distribution, transportation and archiving and unarchiving glass slides. In a context of medical technologists’ shortage of labor, digital pathology platform would allow to assign these important resources for more valuable tasks.
In partnership with the industry, the CHUM acquired modern facilities for the deployment of a high-volume digitization platform. Our project is a project of organizational transformation and aims at exploiting digital technology to its maximum in order to trade traditional diagnostic tools – namely the microscope and glass slides – by scanners and computer screens. We also want to define performance indicators to compare the current workflow with the digital one. In the long term, we want to show that this transfer to full digital is an added value in the efficiency of the practice of pathology that will have a positive impact on the trajectory of care for the benefit of patients, in addition to laying a foundation for future application of artificial intelligence (AI) in pathology.

Partner

  • Centre Hospitalier de l’Université de Montréal

Summary

This project is to expand the use of an innovative developed-in-Quebec person-centered patient portal, Opal (opalmedapps.com), from a single medical speciality (cancer care) to multiple specialities in order to bring its benefits to additional Quebec patients, prove its general utility, and improve its potential marketability. Opal (opalmedapps.com) is a novel person-centered patient portal mobile phone app that was built at and has been released to cancer patients at the Cedars Cancer Centre of the MUHC. As an innovative person-centered patient portal, it not only provides patients with access to their electronic medical records (appointment schedules, lab results, clinical notes, etc.) but also empowers them with automatically-personalized educational material tailored to their disease and phase of treatment; an important feature that is missing from most contemporary patient portals.
This project aims expand the use of Opal to the Montreal Children’s Hospital (MCH), starting with the Nephrology clinic where a detailed study into the clinical and economic impacts of the installation will be undertaken. Lessons learned from deployment of Opal into the MCH will facilitate eventual expansion into all of the departments of the MUHC and potentially into all Quebec healthcare institutions.

Partner

  • McGill University Health Center

Résumé

Rationale: ERAS (Enhanced Recovery After Surgery) is a model-of-care that uses the latest scientific evidence to establish perioperative protocols. It has been shown to reduce post-operative complications by up to 30% and length of stay by 50%. One of the pillars of this performance-oriented model is the audit process. ERAS was implemented on the gynecology / gynecologic oncology unit at the CHUM in March 2018. In order to ensure compliance of the health care team with this new model, the online platform EIAS (ERAS Interactive Audit System) was introduced.
Objectives:
1. Measure the impact of the ERAS program on the quality and the security of the care received by the patients, as well as their experience, by generating data (EIAS)
2. Identify the factors needed for the successful implementation and continued application of the ERAS program
3. Analyze the economic impact of the ERAS program
4. Produce recommendations aimed at facilitating the diffusion of the ERAS model to other surgical subspecialities at the CHUM and our RSSS partners

Method: This qualitative and quantitative study will analyze the implementation process, and the clinical and the economic impact of ERAS at the CHUM. The data will be extracted from the EIAS as well as interviews and questionnaires with the patients and the health care team members.

Impact: Benefits will be seen with regard to the clinical outcomes, the patients, and the efficacy of the care and services provided at the CHUM and at the RSSS level.

Partner

  • Centre Hospitalier de l’Université de Montréal

Summary

The innovation project is the development of a Platform for Evaluation, Intervention and Research in Support of Organizations (PEIRSO) on personality disorders. The platform consists of a secure section for professionals working in the RSSS which will allow 1) to administer a systematic computerized assessment procedure using valid self-administered questionnaires to collect clinical data, in order to document response to interventions by the production of an automated summary report written in a plain language; and 2) to consult valid instruments, interpretation and intervention manuals of evidence-based approaches, training videos, research results, and access to synchronous virtual classes of consultation between colleagues. Access to general information, available resources and useful clinical and bibliographic references on personality disorders will be available to professionals and to the community on the public section. The project addresses the lack of (1) standardized procedure for continuous evaluation of trait severity, impact, intensity, and chronicity of symptoms, as well as the degree of client dysfunction, (2) systematic evaluation of the effectiveness of practices, and (3) widely disseminated evidence-based training programs on personality disorders for professionals.

Partner

  • CIUSSS de la Capitale-Nationale

Summary

Each year, 4600 new cases of prostate cancer are diagnosed in Quebec and 890 men die because of it. Several treatment options are available, including brachytherapy which is a branch of radiotherapy designed to insert a radioactive source into the tumor to deliver local treatment while minimizing the dose to surrounding healthy organs. Patients with prostate cancer are regularly over-dosed or under-dosed when conventional radiotherapy practice is followed. The overall goal of the project is to improve the quality of care provided to our prostate cancer patients treated with high dose rate brachytherapy, while reducing the standard duration of a treatment session and increasing the accuracy in the delivery of this treatment. The new clinical program aims to attack the tumor in a targeted way rather than to treat the entire prostate. The innovative aspects of the technique thus implanted in a real care environment will be; 1. focal prostatic brachytherapy with optimized identification of target volumes and precise delivery of the radiation dose, 2 personalized tumor mapping by MRI multiparametric analysis for the prostate, 3. integration of PET-PSMA (new nuclear medicine radiotracer) into the clinical and decision-making processes. The objective of the current grant proposal is to automate, validate and integrate these different systems in order to make the optimal technique available to our Quebec clinics and ready for a large-scale clinical study.

Partner

  • Centre Hospitalier de l’Université de Montréal

Summary

This project focuses on optimizing the trajectory of care and services in thoracic surgery and is based on real needs expressed by the members of the interdisciplinary teams of the MUHC (referral center) and the CISSSO (affiliated center).  As a referral center, the MUHC benefits from a supra-regional team and leading-edge expertise in oncology and non-oncology cases.  The MUHC performs more than 200 surgeries each year for CISSSO patients. This trajectory of care and services does not currently possess any integrated technological tools to optimally and securely ensure the flow of communications, the transmission of documents and the coordination and monitoring of services.  The project therefore provides for the use of an integrating technological tool, known to Telehealth, and for which certain developments will facilitate accessibility, security, integration and the quality of services and care.
The success of coordination and support of patients will improve the management of their inter-establishment care and may contribute to a more significant improvement in their health. In addition, the effectiveness and efficiency of the trajectory of care and services in thoracic surgery will be improved, as well as better use of resources. The impact of this initiative will also strongly influence other inter-establishment trajectories for all Quebec establishments.

Partner

  • McGill University Health Center

Summary

Access to timely investigation and treatment is critical for reducing the clinical and financial burden of cancer. But how to objectively assess the delays and bottlenecks associated with increased wait times and what are possible solutions? In this project, implemented at the Centre hospitalier de l’Université de Montréal (CHUM), we will apply process mining techniques to improve the health care trajectory of patients with lung cancer. Event logs documenting cancer investigation and treatment will be extracted from the CHUM data lake, thereby allowing to discover processes. Algorithms will generate graphical representations of hospital processes and workflows producing care paths and their associated statistics. To assess conformance, we will compare the actual care processes to lung cancer clinical pathways and performance targets. We will then propose and implement organizational changes leading to greater accessibility and quality, and better resource utilization. Furthermore, we will analyze clinical trajectories and we will characterize the cost per care and services associated with use of immunotherapy for lung cancer. CHUM’s process mining approach builds on an existing clinico-administrative data lake infrastructure developed for the purpose of facilitating research, promoting innovation, and improving performance and clinical relevance. This approach could potentially be replicated at other Quebec institutions with similar data access infrastructures.

Partner

  • Centre Hospitalier de l’Université de Montréal

Summary

In Quebec, providers of psychiatric services are challenged by an increased prevalence of mental problems and suicide on the remote areas. The possibilities provided by modern technological innovations could help to cover unmet needs and to complement traditional psychiatric services. Virtual reality (VR) is well validated as an exposure component to cognitive behavioural therapy in anxiety disorders, including post-traumatic stress disorder. Furthermore, treatments improving coping skills with distress and emotion regulation are increasingly available; efficacy of some applications has been good even as self-management. The aim of this project is to provide adaptive VR treatments for trauma related symptoms. The target groups are Indigenous populations with limited access to specialized care and a need for cultural safety. This project is composed of three studies. First, we test feasibility and acceptability of mobile and VR treatments collecting and analyzing qualitative data among Inuit at the Ullivik centre. Second, we select with stakeholders psychometric instruments to describe symptoms and supportive factors related to psychological trauma. Using qualitative methods, we do translations, cultural adaptations and validation of these scales with Indigenous living in Montreal. Third, we validate psychophysiological measures. Lastly, we want to optimize telemedical device signals and to improve safety and quality of teleconnections between Ullivik and Nunavik communities. The therapy will be offered at home or at a teleclinic using psychophysiological monitoring and telecommunication to guide personalized treatments. The therapy can be complemented with self-management.

Partner

  • CIUSSS de l’Ouest-de-l’Île-de-Montréal

Summary

The 99 Intensive Care Units in Quebec care for the most severely ill patients, whose mortality rate and risk of sequelae are very high. Optimizing the management of each patient and monitoring the quality of each unit would save lives and health costs.
We have developed an intensive care database (BD-SI) containing all the data recorded at high frequency by different technologies at the bedside.
The objectives of our project are:
1- To consolidate the development of the BD-SI and its integration in the CHU Sainte Justine network;
2- Demonstrate the validity of the database;
3- Implement the automatic extraction of quality criteria suggested by INESSS;
4- Demonstrate the feasibility of implementing computerized clinical decision support system on this infrastructure.
This will lead to optimized care for each critical patient, with expected gains in mortality or sequelae, to improved efficiency of critical care professionals, and to an automatic assessment of each unit quality indicators, with benchmarking capacity.

Partner

  • Centre Hospitalier Universitaire Ste-Justine

Partner

Clinical guidelines for stroke rehabilitation recommend at least 15 hours of mobility intervention and 10 hours of communication intervention per week. However, the current schedule of care in clinical programs does not allow for this level of intensity for rehabilitation.
The aim of this participative research project is thus to increase the duration of intervention by providing stroke patients with a circuit of stations where rehabilitation activities can be done autonomously or semi-autonomously, in a group or with relatives to increase their mobility and communication capacities during intensive rehabilitation. Activities would be provided based upon the perceived requirements described by the users, their families and their rehabilitation team. This type of circuit has a good level of evidence in terms of its effect on mobility capacities.
The station set-up and activity monitoring will be administered by a change agent, who will also be involved in the organization of collaborations with external partners, who will provide new technologies and social interventions for rehabilitation that will be tested and improved in a real-world setting. Data collection will include data about the change process and about the effect of this implementation.
This project will thus have an impact on the implementation process of innovative clinical practices, on the establishment of collaborations with external partners and on the clinical benefits during rehabilitation of individuals with stroke.

Partner

  • CIUSSS du Centre-Sud-de-l’Île-de-Montréal

Summary

Real revolution in medical education, the ECHO® (Extension Community Healthcare Outreach) model brings together through multipoint videoconferencing community-based professionals and an expert multidisciplinary team who helps them manage their patient cases via mentoring and feed-back. Partners learn best practice through co-management of diverse patients in real world situations. Over time, these learning loops create deep knowledge, skills and self-efficacy. This hub and spokes approach generates force multiplication; patients are treated without delay, right where they live and according to best-practice care. To date, the model is implanted in 24 countries and applied to 71 chronic health conditions.
In april 2017, we launched at the CHUM in partnership with the integrated University of Montreal health network (RUISSS) the first telementoring ECHO program in Quebec in order to optimize hepatitis C treatment uptake. We were able with the ECHO CHUM hepatitis C 2017-2018 pilot program to demonstrate the feasibility of the ECHO model in Quebec. Two programs were launched since at the CHUM, ECHO Chronic pain, ECHO Mental Health and addiction; two are currently under preparation (opioid substitution therapies and indigenous communities).
The main objective of this project is to promote the implantation of the ECHO model in Quebec through identification of facilitators and barriers to the development of various ECHO programs and evaluation of the benefits of the ECHO Hepatitis C program, precursor of the model in Quebec.

Partner

  • Centre Hospitalier de l’Université de Montréal

Summary

The prevalence of the iatrogenic functional decline is about 20 to 50% for the elderly after an hospitalization. The consequences are the functional incapacities, the mobility loss, the re-hospitalization, the falls and the important use of health care and health services. In this regard, the MSSS adopted in 2011 a framework making mandatory the set up of interventions to prevent the functional decline of hospitalized elderly in every hospital located in Quebec. The Geriatric Assessment Units (GAU) admit elderly around 80 years old who present complex health problems. The scientific literature has shown the effectiveness of rehabilitation programs to ensure the maintenance of functional capacities and the mobility of frail elderly. However, even with these knowledges, the prescription of physical exercises in the GAU does not seem to be integrated as a natural and systematic practice by health the professional.
Our research team would like to implant the clinical tool PATH 2.0 that is a unique process of systematic prescriptions of adapted and specific physical activity program post-hospitalization in the GAU.
The objective of this project is to evaluate the implementation of the clinical tool PATH 2.0 in different GAUs and to evaluate its efficiency and to estimate its cost-effectiveness regarding health care and service used. Finally, the conclusions would help to refine and identify the better procedures to use at short and medium term this clinical tool like a standard practice in GAU and to improve the health continuum of elderly.

Partner

  • CIUSSS du Centre-Ouest-de-l’Île-de-Montréal

Summary

Stroke can affect people’s functioning, social participation and quality of life. It is important to intervene quickly with sufficient intensity of intervention in order to optimize recovery. Waiting lists for the intensive functional rehabilitation (IFR) program and limited resources mean that patients currently do not have access to this level of rehabilitation intensity at the right time. A program called the Early Supported Discharge program (ESD) has been put in place as a solution so that the person can start their IFR at home as soon as they return. Telehealth technologies have been shown to facilitate the process for certain aspects of the ESD program and potentially improve its results.

Thus, the objectives of this study are:
1) To assess the acceptability of the ESD project and telehealth by patients, caregivers and clinicians, as well as their experiences;
2) To assess the degree of integration of telehealth into the clinical activities of the ESD.
3) Assess the impact of ESD use with telehealth on a) patient/family b) clinical care and services.
4) Assess the costs and savings associated with telehealth during the implementation phase.

To meet these objectives, this study will include a pre-implementation evaluation of telehealth, adaptation of a platform to the clinical workflow of the ESD, and an 18-month period of telehealth implementation. These technological solutions are expected to increase the quality and effectiveness of the care provided under the ESD program.

Partner

  • CIUSSS du Centre-Ouest-de-l’Île-de-Montréal

Summary

CaptoMD is the result of 7 years of research efforts at the CHU de Québec—Université Laval with a total funding of $ 1.6M. Our vision is to improve the efficiency, quality and usability of both the clinical care process and the production of data for better care and research. CaptoMD is a cloud platform that offers a set of tools dedicated to clinicians and patients.

The CaptoMD dashboard solves one of the biggest clinical needs, which is to reduce the difficulties of accessing, synthesizing and sharing information. Also, by measuring symptoms and patient-reported outcomes (PROs) and integrating this information into the dashboard, CaptoMD helps to focus the delivery of care on added value for the patient. By capturing all of the clinical data, CaptoMD resolves at the same time the difficulty of producing this information.

CaptoMD has been used for prostate cancer in pilot mode for 3 years at the CHU de Québec. This project will continue our efforts to add new evidence in a clinical setting to demonstrate CaptoMD’s contribution to the practice of modern medicine.

Thus, the objectives of the project are:
1. Describe the challenges of implementing CaptoMD
2. Implantation of CaptoMD in prostate cancer at the CHU de Québec
3. Evaluate the impacts of CaptoMD
4. Adapt CaptoMD to other tumor sites

Partner

  • CHU de Québec – Université Laval

Summary

Québec is extremely well positioned to take advantage of the unique strengths of its university and hospital network to become a world leader in the emerging field of gene therapy, a treatment that applies primarily to cancer but will soon be a must for many other diseases.

Gene therapy is a treatment strategy that involves the entry of genes into an individual’s cells either to replace defective cellular elements or to add functional elements. For its application in humans, the crucial step of producing viral vectors that deliver this genetic material under conditions of Good Manufacturing Practice (GMP) requires an important step of validation.
The objective of the project is to validate viral production in our GMP environment in order to confirm the quality of production and thus produce a clinical and commercial level cellular material. This demonstration will be carried out under real conditions (not simulated) according to all the extremely strict rules of BPF. This involves the validation of equipment and procedures, as well as quality control testing.

At the end of the project, we will be able to apply this viral vector production technology in real production conditions and so we will have confirmation that we can achieve a clinical viral vector production, which represents the ability to produce commercial level viral vectors for patients.

Partner

  • CIUSSS de l’Est-de-l’Île-de-Montréal